Formulating fast dissolving tablet (FDT) using solid dispersion of drug shall not only improve solubility and consequent bioavailability but also improved patient compliance and convenience. The aim of the present study was to improve the solubility of candesartan cilexetil (CAN) by solid dispersion (SD) technique and formulate it as fast dissolving tablets using superdisintegrants. Solid dispersion of CAN was prepared by physical mixture, kneading, solvent evaporation, microwave irradiation method using polyethylene glycol (PEG) 4000 and PEG 6000 as a carrier. Different weight ratios of drug and carrier i.e. 1:1, 1:2, 1:3, 1:4 and 1:5 were taken. Solubility of drug was determined in physical mixture and SD formulations. The prepared SD formulations were characterized by fourier transform infra-red (FTIR), differential scanning calorimetry (DSC), x-ray diffraction (XRD) and in-vitro drug release. FDT of CAN was formulated using optimized SD formulation of drug and carrier along with the superdisintegrant such as crosscarmellose sodium. From FTIR, DSC and XRD studies, it was concluded that there is change in crystalline form of drug into amorphous formulation of SD. Fast dissolving tablet containing crosscarmellose sodium (5%) as superdisintegrant showed the fastest disintegration (30 sec) and in-vitro drug release (98.2%). It can conclude that combination of SD and superdisintegrants is promising approach to prepare efficient FDT of candesartan cilexetil.
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